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1

Interleukin-6: designing specific therapeutics for a complex cytokine

Garbers, Christoph, Heink, Sylvia, Korn, Thomas, Rose-John, Stefan

Journal:

Nature Reviews Drug Discovery

Year:

2018

Language:

english

File:

PDF, 704 KB

english, 2018

2

ADAM17: a molecular switch to control inflammation and tissue regeneration

Jürgen Scheller, Athena Chalaris, Christoph Garbers, Stefan Rose-John

Journal:

Trends in Immunology

Year:

2011

Language:

english

File:

PDF, 489 KB

english, 2011

3

IL-6 biology: implications for clinical targeting in rheumatic disease

Calabrese, Leonard H., Rose-John, Stefan

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2014

Language:

english

File:

PDF, 838 KB

english, 2014

4

Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage

Prenissl, Niklas, Lokau, Juliane, Rose-John, Stefan, Haybaeck, Johannes, Garbers, Christoph

Journal:

Year:

2019

Language:

english

File:

PDF, 554 KB

english, 2019

5

Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19

Garbers, Christoph, Rose-John, Stefan

Journal:

The Lancet Rheumatology

Year:

2020

File:

PDF, 43 KB

2020

6

Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors

Pia März, Uwe Otten, Stefan Rose-John

Journal:

European Journal of Neuroscience

Year:

1999

Language:

english

File:

PDF, 500 KB

english, 1999

7

Is Interleukin-6 Receptor Blockade the Holy Grail for Inflammatory Diseases?

Febbraio, M A, Rose-John, S, Pedersen, B K

Journal:

Clinical Pharmacology & Therapeutics

Year:

2010

Language:

english

File:

PDF, 90 KB

english, 2010

8

The IL-6/sIL-6R complex as a novel target for therapeutic approaches

Rose-John, Stefan, Waetzig, Georg H, Scheller, Jürgen, Grötzinger, Joachim, Seegert, Dirk

Journal:

Expert Opinion on Therapeutic Targets

Year:

2007

Language:

english

File:

PDF, 377 KB

english, 2007

9

Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN

Luig, M., Kluger, M. A., Goerke, B., Meyer, M., Nosko, A., Yan, I., Scheller, J., Mittrucker, H.-W., Rose-John, S., Stahl, R. A. K., Panzer, U., Steinmetz, O. M.

Journal:

Journal of the American Society of Nephrology

Year:

2015

Language:

english

File:

PDF, 2.02 MB

english, 2015

10

Inhibition of T Cell Apoptosis in the Aqueous Humor of Patients with Uveitis by IL-6/Soluble IL-6 Receptor trans-Signaling

Curnow, S. J., Scheel-Toellner, D., Jenkinson, W., Raza, K., Durrani, O. M., Faint, J. M., Rauz, S., Wloka, K., Pilling, D., Rose-John, S., Buckley, C. D., Murray, P. I., Salmon, M.

Journal:

The Journal of Immunology

Year:

2004

Language:

english

File:

PDF, 767 KB

english, 2004

11

The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition

Garbers, Christoph, Aparicio-Siegmund, Samadhi, Rose-John, Stefan

Journal:

Current Opinion in Immunology

Year:

2015

Language:

english

File:

PDF, 1.26 MB

english, 2015

12

A Disintegrin and Metalloprotease (ADAM) 10 and ADAM17 Are Major Sheddases of T Cell Immunoglobulin and Mucin Domain 3 (Tim-3)

Moller-Hackbarth, K., Dewitz, C., Schweigert, O., Trad, A., Garbers, C., Rose-John, S., Scheller, J.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 3.30 MB

english, 2013

13

Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor

Garbers, C., Thaiss, W., Jones, G. W., Waetzig, G. H., Lorenzen, I., Guilhot, F., Lissilaa, R., Ferlin, W. G., Grotzinger, J., Jones, S. A., Rose-John, S., Scheller, J.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 3.44 MB

english, 2011

14

Peripheral and central blockade of interleukin-6 trans-signaling differentially affects sleep architecture

Oyanedel, Carlos N., Kelemen, Eduard, Scheller, Jürgen, Born, Jan, Rose-John, Stefan

Journal:

Brain, Behavior, and Immunity

Year:

2015

Language:

english

File:

PDF, 1.56 MB

english, 2015

15

“Family reunion” – A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines

Rose-John, Stefan, Scheller, Jürgen, Schaper, Fred

Journal:

Cytokine & Growth Factor Reviews

Year:

2015

Language:

english

File:

PDF, 521 KB

english, 2015

16

IL-6 Trans-Signaling Drives Murine Crescentic GN

Braun, G. S., Nagayama, Y., Maruta, Y., Heymann, F., van Roeyen, C. R., Klinkhammer, B. M., Boor, P., Villa, L., Salant, D. J., Raffetseder, U., Rose-John, S., Ostendorf, T., Floege, J.

Journal:

Journal of the American Society of Nephrology

Year:

2016

Language:

english

File:

PDF, 1.84 MB

english, 2016

17

IL-6 trans-signaling promotes KRAS-driven lung carcinogenesis

Brooks, G. D., McLeod, L., Alhayyani, S., Miller, A., Russell, P. A., Ferlin, W., Rose-John, S., Ruwanpura, S., Jenkins, B. J.

Journal:

Cancer Research

Year:

2016

Language:

english

File:

PDF, 17.68 MB

english, 2016

18

The role of interleukin-6 signaling in nervous tissue

Rothaug, Michelle, Becker-Pauly, Christoph, Rose-John, Stefan

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2016

Language:

english

File:

PDF, 663 KB

english, 2016

19

Interleukin-6 Family Cytokines

Rose-John, Stefan

Journal:

Cold Spring Harbor Perspectives in Biology

Year:

2017

Language:

english

File:

PDF, 10.24 MB

english, 2017

20

The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma

Lenk, Lennart, Pein, Maren, Will, Olga, Gomez, Beatriz, Viol, Fabrice, Hauser, Charlotte, Egberts, Jan-Hendrik, Gundlach, Jan-Paul, Helm, Ole, Tiwari, Sanjay, Weiskirchen, Ralf, Rose-John, Stefan, Röc

Journal:

Year:

2017

Language:

english

File:

PDF, 4.17 MB

english, 2017

21

A new multiple trauma model of the mouse

Fitschen-Oestern, Stefanie, Lippross, Sebastian, Klueter, Tim, Weuster, Matthias, Varoga, Deike, Tohidnezhad, Mersedeh, Pufe, Thomas, Rose-John, Stefan, Andruszkow, Hagen, Hildebrand, Frank, Steubesan

Journal:

BMC Musculoskeletal Disorders

Year:

2017

Language:

english

File:

PDF, 1.04 MB

english, 2017

22

Correction to: A new multiple trauma model of the mouse

Fitschen-Oestern, Stefanie, Lippross, Sebastian, Klueter, Tim, Weuster, Matthias, Varoga, Deike, Tohidnezhad, Mersedeh, Pufe, Thomas, Rose-John, Stefan, Andruszkow, Hagen, Hildebrand, Frank, Steubesan

Journal:

BMC Musculoskeletal Disorders

Year:

2019

Language:

english

File:

PDF, 393 KB

english, 2019

23

Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles

Arnold, Philipp, LÃ¼ckstÃ¤dt, Wiebke, Li, Wenjia, Boll, Inga, Lokau, Juliane, Garbers, Christoph, Lucius, Ralph, Rose-John, Stefan, Becker-Pauly, Christoph

Journal:

Year:

2020

File:

PDF, 1.83 MB

2020

24

ADAM17 Deficiency Protects Against Pulmonary Emphysema

Saad, Mohamed I., McLeod, Louise, Hodges, Christopher, Vlahos, Ross, Rose-John, Stefan, Ruwanpura, Saleela, Jenkins, Brendan J

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2020

File:

PDF, 2.71 MB

2020

25

Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain

Dobert, Jan Philipp, Cabron, Anne-Sophie, Arnold, Philipp, Pavlenko, Egor, Rose-John, Stefan, Zunke, Friederike

Journal:

Year:

2020

File:

PDF, 1.88 MB

2020

26

The family of the IL-6-Type cytokines: Specificity and promiscuity of the receptor complexes

Joachim Grotzinger, Günther Kurapkat, Axel Wollmer, Michael Kalai, Stefan Rose-John

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1997

Language:

english

File:

PDF, 510 KB

english, 1997

27

Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons

M. Thier, P. März, U. Otten, J. Weis, S. Rose-John

Journal:

Journal of Neuroscience Research

Year:

1999

Language:

english

File:

PDF, 516 KB

english, 1999

28

Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression

Pia März, Klaus Heese, Beatrice Dimitriades-Schmutz, Stefan Rose-John, Uwe Otten

Journal:

Year:

1999

Language:

english

File:

PDF, 286 KB

english, 1999

29

Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection

Wulf O. Böcher, Benjamin Dekel, Wibke Schwerin, Michael Geissler, Sina Hoffmann, Andreas Rohwer, Fabian Arditti, Aric Cooper, Helga Bernhard, Alain Berrebi, Stefan Rose-John, Yosef Shaul, Peter R. Gal

Journal:

European Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 142 KB

english, 2001

30

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis

Peter J. Richards, Mari A. Nowell, Sankichi Horiuchi, Rachel M. McLoughlin, Ceri A. Fielding, Sandra Grau, Naoki Yamamoto, Michael Ehrmann, Stefan Rose-John, Anwen S. Williams, Nicholas Topley, Simon

Journal:

Arthritis & Rheumatism

Year:

2006

Language:

english

File:

PDF, 867 KB

english, 2006

31

Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth

Steve Lacroix, Leon Chang, Stefan Rose-John, Mark H. Tuszynski

Journal:

The Journal of Comparative Neurology

Year:

2002

Language:

english

File:

PDF, 1.10 MB

english, 2002

32

Microheterogeneity of human interleukin 6 synthesized by transfected NIH/3T3 cells: Comparison with human monocytes, fibroblasts and endothelial cells

Xaver Schiel, Stefan Rose-John, Gabi Dufhues, Heidi Schooltink, Volker Gross, Peter C. Heinrich

Journal:

European Journal of Immunology

Year:

1990

Language:

english

File:

PDF, 612 KB

english, 1990

33

The soluble interleukin-6 receptor is generated by shedding

Jürgen Mülberg, Heidi Schooltink, Tanja Stoyan, Monika Günther, Lutz Graeve, Gerhard Buse, Andrzej Mackiewicz, Peter C. Heinrich, Stefan Rose-John

Journal:

European Journal of Immunology

Year:

1993

Language:

english

File:

PDF, 2.51 MB

english, 1993

34

Genetic manipulations utilizing albumin and alpha-fetoprotein promoter/enhancers affect both hepatocytes and oval cells

Vance B. Matthews, Stefan Rose-John, George C. T. Yeoh

Journal:

Year:

2004

Language:

english

File:

PDF, 88 KB

english, 2004

35

Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation

George C. T. Yeoh, Matthias Ernst, Stefan Rose-John, Barbara Akhurst, Christine Payne, Sarah Long, Warren Alexander, Ben Croker, Dianne Grail, Vance B. Matthews

Journal:

Year:

2007

Language:

english

File:

PDF, 1.79 MB

english, 2007

36

Site-directed mutagenesis of human CNTF: Functional analysis of recombinant variants

M. Thier, R. Simon, A. Krüttgen, S. Rose-John, P. C. Heinrich, J. M. Schröder, Dr. J. Weis

Journal:

Journal of Neuroscience Research

Year:

1995

Language:

english

File:

PDF, 1.71 MB

english, 1995

37

Activation of interleukin-6–induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration

Shuk Pik Lam, John M. Luk, Kwan Man, Kevin T. P. Ng, Cindy K. Cheung, Stefan Rose-John, Chung Mau Lo

Journal:

Liver Transplantation

Year:

2010

Language:

english

File:

PDF, 567 KB

english, 2010

38

A NOVEL AND RAPID PREDICTION ASSAY FOR THE EFFECTIVENESS OF IL-6 RECEPTOR SPECIFIC ANTISENSE OLIGONUCLEOTIDES BY PROLIFERATION INHIBITION OF AN INTERLEUKIN-6 DEPENDENT CELL LINE

Valeria Lia Varga, Andras Falus, Eva Pallinger, István Novák, Kristóf A. Fülöp, Sara Toth, Stefan Rose-John

Journal:

Cell Biology International

Year:

2001

Language:

english

File:

PDF, 123 KB

english, 2001

39

Transglutaminase-catalyzed covalent multimerization of camelidae anti-human TNF single domain antibodies improves neutralizing activity

Ingo Plagmann, Athena Chalaris, Andrei A. Kruglov, Sergei Nedospasov, Philip Rosenstiel, Stefan Rose-John, Jürgen Scheller

Journal:

Journal of Biotechnology

Year:

2009

Language:

english

File:

PDF, 844 KB

english, 2009

40

Soluble interleukin-6 receptor (sIL-6R) makes IL-6R negative T cell line respond to IL-6; it inhibits TNF production

Peter Igaz, Attila Horváth, Barbara Horváth, Csaba Szalai, Éva Pállinger, Éva Rajnavölgyi, Sara Tóth, Stefan Rose-John, András Falus

Journal:

Immunology Letters

Year:

2000

Language:

english

File:

PDF, 160 KB

english, 2000

41

Genetically modified tumour vaccines (GMTV) in melanoma clinical trials

Sergiusz Nawrocki, Paweł Murawa, Julian Malicki, Malgorzata Kapcinska, Katarzyna Gryska, Dariusz Izycki, Aldona Kaczmarek, Maria Laciak, Anna Czapczyk, Aldona Karczewska, Stefan Rose-John, Andrzej Mac

Journal:

Immunology Letters

Year:

2000

Language:

english

File:

PDF, 137 KB

english, 2000

42

The function of the soluble IL-6 receptor in vivo

Malte Peters, Karl-Hermann Meyer zum Büschenfelde, Stefan Rose-John

Journal:

Immunology Letters

Year:

1996

Language:

english

File:

PDF, 700 KB

english, 1996

43

Immuno-gene therapy of human melanoma. Phase I/II clinical trial

A. Mackiewicz, M. Kapcińska, M. Wiznerowicz, J. Malicki, J. Nowak, P. Murawa, E. Sibilska, M. Kowalczyk, A. Lange, R.C. Hawley, S. Rose-John

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 179 KB

english, 1997

44

Mechanisms of induction of antimelanoma immune response by murine melanoma cells modified to secrete IL-6 and sIL-6R

D. Iżycki, V. Filas, K. Gryska, S. Rose-John, A. Mackiewicz

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 188 KB

english, 1997

45

239. Ocena efektu przeciwnowotworowego genetycznie modyfikowanej szczepionki komórkowej w mysim modelu raka nerki

P.J. Wysocki, D.W. Kowalczyk, P. Grabarczyk, M. Mackiewicz-Wysocka, H. Dams-Kozłowska, S. Rose-John, A. Mackiewicz

Journal:

Reports of Practical Oncology & Radiotherapy

Year:

2003

Language:

polish

File:

PDF, 109 KB

polish, 2003

46

101P Indukcja immunologicznej odpowiedzi przeciwczerniakowej przez interleukinę 6 w modelu myszy knock out

D. Iżycki, V. Filas, M. Kopf, S. Rose-John, K. Gryska, A. Mackiewicz

Journal:

Reports of Practical Oncology & Radiotherapy

Year:

1998

Language:

polish

File:

PDF, 281 KB

polish, 1998

47

Regulation of endotoxin-induced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10

P. A. KNOLLE, E. LO¨SER, U. PROTZER, R. DUCHMANN, E. SCHMITT, K.-H. M. ZUM BU¨SCHENFELDE, S. ROSE-JOHN, G. GERKEN

Journal:

Clinical & Experimental Immunology

Year:

1997

Language:

english

File:

PDF, 581 KB

english, 1997

48

Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B – restoration by exogenous interleukin-12

H. F. LÖHR, S. PINGEL, W. O. BÖCHER, H. BERNHARD, S. HERZOG-HAUFF, S. ROSE-JOHN

Journal:

Clinical & Experimental Immunology

Year:

2002

Language:

english

File:

PDF, 134 KB

english, 2002

49

Possible role of human interleukin-6 and soluble interleukin-6 receptor in hepatitis B virus infection

D. Heinz, M. Peters, R. Prange, G. Gerken, S. Rose-John

Journal:

Journal of Viral Hepatitis

Year:

2001

Language:

english

File:

PDF, 732 KB

english, 2001

50

Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor

Pia März, Suat Özbek, Martina Fischer, Nicole Voltz, Uwe Otten, Stefan Rose-John

Journal:

Year:

2002

Language:

english

File:

PDF, 261 KB

english, 2002

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